![]() Moreover, we showed that M-cadherin–dependent adhesion activates Rac1 and demonstrated the formation of a multiproteic complex containing M-cadherin, the Rho-GEF Trio, and Rac1 at the onset of myoblast fusion. ![]() We found that the Rac1 GTPase activity is increased at the time of myoblast fusion and it is required for this process. ![]() The goal of this study was to cast some light on the nature of the M-cadherin–mediated signals involved in myoblast fusion into myotubes. ![]() M-cadherin is required for myoblast fusion into myotubes, but its mechanisms of action remain unknown. Cadherins are transmembrane glycoproteins that mediate Ca 2+-dependent homophilic cell–cell adhesion and play crucial role during skeletal myogenesis.
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